Fosfomycin Disodium

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

磷霉素是一种杀菌、低分子量、广谱抗生素，通过不可逆地抑制细胞壁合成的早期阶段，对多种细菌（包括多重耐药革兰氏阴性菌）具有假定活性。

Fosfomycin is a bactericidal low-molecular weight broad-spectrum antibiotic with putative activity against several bacteria including multidrug-resistant Gram-negative bacteria by irreversibly inhibiting an early stage in cell wall synthesis.

Fosfomycin sodium is an epoxy antibacterial agent. Compared with other antibacterial agents, it acts by inhibiting the early process of cell wall synthesis.Fosfomycin sodium has bactericidal activity against a variety of gram-negative and gram-positive pathogens, including broad-spectrum production β-Bacteria of lactamase and carbapenemase, and against S. aureus strains with an inhibition rate of 90%.Fosfomycin sodium displays extensive tissue penetration, can be used to research of infections of the CNS, soft tissues, bone, lungs, and abscesses.

Fosfomycin sodium (80 mg/kg; i.v.-i.v. or i.v.-p.o.) displays the protective effect on the nephrotoxicity of double beckacin, and is not affected by different administration routes.Pharmacokinetic of Fosfomycin sodium in Rats. Animal Model:Fischer 344 rats Dosage:320 mg/kg Administration:Intramuscular injection, 5 schedules: 1 h, 0.5 h earlier than dibekacin, concomitantly, 0.5 h later and 1 h later; 11 days Result:Reduced polyuria, proteinuria, enzymes and cytosine caused by dibecacin (40 mg/kg), followed by the previous treatment.Animal Model:Dehydrated Wistar rat with acute renal failure (8-week-old)Dosage:120 mg/kg Administration:Intravenous injection; once Result:Recovered the exclusion rate of rats basically to normal, and improved the nephrotoxicity parameters.Protects proximal tubular lysosomes from aminoglycosides by inhibiting myeloid formation and protecting the integrity of lysosomal membrane of rats treated with double bekacin.

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GPCR/G Protein

Antibacterial

Antibacterial

Infection

Urinary Tract InfectionAsymptomatic Bacteriuria

26016-99-9

182.02

C3H5Na2O4P

>98% (HPLC)

H2O:36 mg/mL (197.78 mM)

C[C@@H]1O[C@@H]1P([O-])([O-])=O.[Na+].[Na+]

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(-20℃)

With Ice Pack

≥ 2 years